Aspire Biopharma Holdings, Inc. is an early-stage biopharmaceutical company that develops and markets technology for novel sublingual delivery mechanisms in the United States. Its sublingual aspirin product is a soluble, pH-neutral, fast-acting aspirin intended for cardiology emergencies and pain management. The company is also developing sublingual formulations of melatonin sleep aids; vitamins D, E, and K; testosterone; and semaglutide, as well as anti-nausea products, anti-psychotic products, ED drugs, seizure medication, and other drug classes, plus caffeine products such as a single-dose sublingual pre-workout supplement. Founded in 2021, it is headquartered in Estero, Florida.