AstraZeneca trial setback drags FTSE 100 lower

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London's FTSE 100 underperformed European peers, closing down 0.2% at 10,472.45, as a 6.2% slump in AstraZeneca weighed on the index. The pharmaceutical giant's cardiovascular drug Wainua failed to meet its primary endpoint in a phase three trial for transthyretin-mediated amyloid cardiomyopathy, prompting analysts to question management credibility and forecast the removal of most of the drug's 3.3 billion US dollars risk-adjusted peak sales consensus. The decline in AstraZeneca, the second-highest weighted stock in the FTSE 100, offset gains in mining stocks such as Antofagasta, Anglo American, and Glencore, which rose on higher metal prices. Meanwhile, the FTSE 250 added 1.0% and the AIM All-Share gained 0.6%, with Computacenter and Playtech among notable risers after upbeat outlooks.

Impact on stocks 10

Critical Materials & Supply Chain▲ · 3 stocks
Biotech & Genomic Medicine▼ · 2 stocks
AstraZeneca PLC
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AstraZeneca's drug Wainua failed phase three trial, missing primary endpoint, leading to analyst downgrades and removal of peak sales consensus.

Industrials▲ · 1 stocks
Cybersecurity & Digital Trust▲ · 1 stocks
Cloud & Digital Infrastructure▲ · 1 stocks
Consumer Staples▲ · 1 stocks
Consumer Discretionary▲ · 1 stocks

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