AstraZeneca tumbles 9% after heart drug trial misses primary endpoint

EarningsCorporate Action Impact 4
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Summary · why it matters

AstraZeneca shares fell 9% after its Phase 3 CARDIO-TTRansform trial of Wainua, developed with Ionis Pharmaceuticals, failed to meet its primary endpoint in patients with transthyretin-mediated amyloid cardiomyopathy. The study did not show a significant improvement in the composite of cardiovascular mortality and recurrent cardiovascular events versus placebo through 140 weeks. Ionis Pharmaceuticals shares declined 8% on the news. Separately, Ampco-Pittsburgh jumped 14% after reporting first-half 2026 customer orders rose 32% year-over-year to $268 million, driven by strength in both operating segments. Levi Strauss fell 6% despite better-than-expected second-quarter revenue and earnings, as its full-year earnings per share outlook midpoint of $1.49 came in below the $1.51 consensus, with the company assuming 30% U.S. tariffs on Chinese imports and 20% tariffs on imports from the rest of the world remain in place through year-end. MDA Space slid 6% after agreeing to acquire a roughly 70% stake in France-based CLS for €567 million and announcing a C$712 million bought-deal equity offering to help finance the transaction.

Impact on stocks 5

Biotech & Genomic Medicine▼ · 2 stocks
AstraZeneca PLC
AZN
▼ NegativeTechnologyrelevance

Phase 3 CARDIO-TTRansform trial of Wainua failed to meet primary endpoint.

Ionis Pharmaceuticals Inc
IONS
▼ NegativeTechnologyrelevance

Phase 3 CARDIO-TTRansform trial of Wainua failed to meet primary endpoint in patients with transthyretin-mediated amyloid cardiomyopathy.

Materials▲ · 1 stocks
Ampco-Pittsburgh Corporation
AP
▲ PositiveDemandrelevance

First-half 2026 customer orders rose 32% year-over-year to $268 million, driven by strength in both operating segments.

Consumer Discretionary▼ · 1 stocks
Levi Strauss & Co Class A
LEVI
▼ NegativeCapitalrelevance

Full-year earnings per share outlook midpoint of $1.49 came in below $1.51 consensus, with tariff assumptions.

Industrials▲ · 1 stocks

Theme Impact 1

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