BridgeBio Reports Signs of Cardiac Reversal With Acoramidis

Earnings
โดย Insider Monkey·US·Read original
Summary · why it matters

BridgeBio Pharma reported new cardiac magnetic resonance imaging data from the Phase 3 ATTRibute-CM study and its open-label extension, suggesting that some acoramidis-treated patients experienced improvements in cardiac structure and function. In a completer analysis, 54% of acoramidis-treated patients achieved a clinically meaningful improvement in left ventricular systolic function at Month 30, compared with 20% of placebo-treated patients, while a more conservative analysis showed improvement in 34% of acoramidis-treated patients versus 9% of placebo-treated patients. Acoramidis also reduced the estimated mean percentage of days lost to death or cardiovascular hospitalization to 7.5% from 11.7% with placebo through Month 30, translating to 38 additional days alive outside the hospital, with the difference reaching 65 days by Month 36. However, these exploratory analyses are not randomized and cannot establish disease reversal, and no head-to-head comparison with competing therapies was provided. BridgeBio has initiated ASCEND-ATTR, a Phase 3b/4 study to prospectively evaluate sustained improvement in cardiac structure, function, and amyloid burden.

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New Phase 3 data suggests acoramidis may improve cardiac structure and function, a positive development for the drug.

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