Bristol Myers Squibb Presents Five-Year Camzyos Data at ESC Congress

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โดย Business Wire·US·Read original
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Bristol Myers Squibb presented results from the EXPLORER-LTE cohort of the MAVA-LTE study at the European Society of Cardiology Congress 2026, showing that Camzyos (mavacamten) provides sustained efficacy and safety for up to five years in patients with symptomatic obstructive hypertrophic cardiomyopathy. The single-arm, open-label extension of the Phase 3 EXPLORER-HCM study included 231 patients, with 97.4% achieving a Valsalva left ventricular outflow tract gradient of 30 mm Hg or less, 69.6% improving by at least one New York Heart Association class, and 59.2% becoming asymptomatic at 252 weeks. Mean resting and Valsalva LVOT gradients decreased by 38.7 mm Hg and 55.6 mm Hg, respectively, while left ventricular ejection fraction decreased by 10.2% but remained within normal range. Additional real-world data from the COLLIGO-HCM study and a German registry reinforced the drug's effectiveness across diverse populations, and a Swedish healthcare resource utilization study highlighted the disease burden of HCM. No new safety signals emerged, and the findings support Camzyos as the most-studied cardiac myosin inhibitor, with over 25,000 patients treated in the U.S. alone.

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