CervoMed Inc.Completed enrollment in Phase 2a study of neflamapimod for a tau-related dementia with no approved treatments, and highlighted preclinical data showing reversal of axonal transport deficits.

CervoMed has completed enrollment in its Phase 2a study of neflamapimod for nonfluent variant primary progressive aphasia, a type of frontotemporal dementia. The trial enrolled 25 participants who will receive oral neflamapimod for 24 weeks, followed by a 12-week randomized, double-blind placebo-controlled extension. Interim biomarker data from the study will be presented at the 19th Clinical Trials on Alzheimer's Disease conference in Boston in November 2026, with first clinical data expected in the first quarter of 2027. The company also highlighted a recent Nature Neuroscience publication demonstrating that p38α inhibition with neflamapimod reversed axonal transport deficits in a mouse model of tau-related frontotemporal dementia. Nonfluent variant primary progressive aphasia, the most common tau-associated frontotemporal dementia subtype, has no approved treatments in the United States or European Union.
CervoMed Inc.Completed enrollment in Phase 2a study of neflamapimod for a tau-related dementia with no approved treatments, and highlighted preclinical data showing reversal of axonal transport deficits.