CervoMed Inc.New clinical data and biomarker analyses support neflamapimod's efficacy in DLB, with identified dose for Phase 3.

CervoMed announced new clinical, plasma biomarker, and imaging data for neflamapimod in dementia with Lewy bodies at the Alzheimer's Association International Conference 2026. New analyses from the 159-patient Phase 2b RewinD-LB trial indicate that the failure to replicate earlier Phase 2a results was due to a higher-than-targeted proportion of patients with Alzheimer's disease co-pathology and use of a drug batch that did not achieve expected plasma concentrations. Exploratory analyses showed neflamapimod slowed worsening of DLB in patients with low plasma pTau181 and in those who achieved expected drug levels, with a consistently improving treatment effect at progressively lower pTau181 levels. Neflamapimod also demonstrated durable slowing of right basal forebrain atrophy and increased basal forebrain connectivity relative to placebo over 48 weeks. A separate Phase 2 study of an 80 mg twice-daily dose met its primary safety, tolerability, and pharmacokinetic objectives, and a pharmacokinetic-pharmacodynamic analysis identified a plasma trough threshold of about 4 ng/mL associated with clinical improvements, supporting selection of a 50 mg three-times-daily dose for the planned Phase 3 trial.
CervoMed Inc.New clinical data and biomarker analyses support neflamapimod's efficacy in DLB, with identified dose for Phase 3.