Denali Therapeutics IncCEO to deliver opening plenary at AAIC 2026, highlighting BBB breakthroughs and pipeline progress including DNL628 and DNL921.

Denali Therapeutics announced that co-founder and CEO Ryan Watts will deliver the opening plenary address at the Alzheimer’s Association International Conference 2026 in London on July 12. The presentation will cover recent scientific advances and future opportunities in neurodegenerative disease drug development, including new insights into disease biology, biomarker use, and the potential for therapeutics to cross the blood-brain barrier. Denali is advancing multiple investigational therapies for Alzheimer’s disease that leverage its TransportVehicle platform, which has been clinically validated with the FDA accelerated approval of AVLAYAH for Hunter syndrome in March 2026. Among its pipeline, DNL628 targets tau via the Oligonucleotide TransportVehicle and began Phase 1b dosing in the first half of 2026, with proof-of-concept data expected in 2027. DNL921 targets amyloid beta via the Antibody TransportVehicle and has a Clinical Trial Application submitted, with a Phase 1/1b trial anticipated to start pending regulatory approval and potential data also in 2027.
Denali Therapeutics IncCEO to deliver opening plenary at AAIC 2026, highlighting BBB breakthroughs and pipeline progress including DNL628 and DNL921.