Evotec SEEvotec's biologics subsidiary initiated a Phase 1 trial for JST-018, an orthopoxvirus antibody cocktail developed under the U.S. Department of War's Accelerated Antibodies Program.

Evotec SE announced the initiation of a Phase 1 clinical trial for JST-018, a cocktail of investigational monoclonal antibodies targeting orthopoxviruses, developed by its biologics CDMO subsidiary Just – Evotec Biologics under the U.S. Department of War's Accelerated Antibodies Program. The program advanced from antibody sequence selection through preclinical development, process development, regulatory submission, and cGMP manufacture, with manufacturing completed at the J.POD® facility in Redmond, Washington. This milestone fulfills the scope of a 2023 contract with the U.S. Department of War, which is the second such award under the Accelerated Antibodies Program, following an initial 2022 award for plague antibodies; together, the two contracts have a combined potential value of up to $123.9 million. JST-018 is being developed as a prophylactic therapy to protect warfighters from orthopoxvirus threats, which include smallpox and mpox viruses.
Evotec SEEvotec's biologics subsidiary initiated a Phase 1 trial for JST-018, an orthopoxvirus antibody cocktail developed under the U.S. Department of War's Accelerated Antibodies Program.