MannKind CorpPositive Phase 1b results for inhaled nintedanib in IPF, showing safety and tolerability, advancing the pipeline.

MannKind Corporation announced positive topline results from its Phase 1b INFLO-1 study of nintedanib dry powder inhalation in patients with idiopathic pulmonary fibrosis. The study met its primary objective, demonstrating that nintedanib DPI was generally safe and well tolerated, with no serious adverse events, no drug-related gastrointestinal side effects, no bronchospasm events, and no treatment discontinuations or dose reductions. Most patients experienced no cough, and reported cough events were predominantly mild, transient, and resolved. Across the completed Phase 1a and Phase 1b studies, a total of 48 individuals have received nintedanib DPI, including nearly 450 inhalations administered to people living with IPF. MannKind's global Phase 2 INFLO-2 study is actively enrolling patients with IPF, with approximately 210 participants expected across roughly 85 sites worldwide.
MannKind CorpPositive Phase 1b results for inhaled nintedanib in IPF, showing safety and tolerability, advancing the pipeline.