Quest Diagnostics IncorporatedQuest Diagnostics provided samples for the study, but the article does not indicate a direct impact on its business; the findings may highlight a need for new diagnostics, but no specific effect is stated.

A national study published in Nature Communications finds that 69.5 percent of Klebsiella pneumoniae samples collected across 42 states were non-susceptible to the three most commonly used oral antibiotics. Scientists from the Hackensack Meridian Center for Discovery and Innovation and Quest Diagnostics screened more than 2,000 samples and identified 267 multidrug-resistant sequence types, with all bacteria classified as multidrug resistant. The gene CTX-M-15, easily swapped between bacteria on plasmids, is driving the resistance and also conferring stress and metal tolerance that may enhance survival outside human hosts. The research reveals a shift from healthcare-associated infections to widespread community reservoirs, with over two-thirds of samples from female patients and about three-quarters from people older than 60. Authors say the findings underscore the urgent need for new oral treatment options and provide a genetic blueprint for developing vaccines or other therapies.
Quest Diagnostics IncorporatedQuest Diagnostics provided samples for the study, but the article does not indicate a direct impact on its business; the findings may highlight a need for new diagnostics, but no specific effect is stated.