Nectin Therapeutics reports encouraging Phase 1 results for NTX1088 with Keytruda at ASCO 2026

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Nectin Therapeutics announced Phase 1 results showing its first-in-class anti-CD155 antibody NTX1088 combined with Merck's Keytruda was well tolerated and demonstrated preliminary anti-tumor activity in heavily pretreated patients with advanced solid tumors. The data were presented at the 2026 ASCO annual meeting. Among 41 evaluable patients receiving active dose levels of NTX1088 with pembrolizumab, confirmed partial responses were observed across multiple tumor types including gastric, bladder, non-small cell lung cancer, head and neck squamous cell carcinoma, and melanoma. The study population had a median of four prior lines of therapy and high rates of prior checkpoint inhibitor exposure. A dose of 1,750 mg was selected for expansion, and most responding patients were ongoing at data cutoff with a maximum treatment duration of 24 months.

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Biotech & Genomic Medicine▲ · 1 stocks
Merck & Company Inc
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▲ PositiveDemandTechnologyrelevance

NTX1088 is combined with Merck's Keytruda, and positive results may support Keytruda's use in combination, potentially boosting demand.

Critical Materials & Supply Chain▲ · 1 stocks

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Off-coverage companies 1

Nectin TherapeuticsPrivate▲ Positive
Technologyrelevance

Encouraging Phase 1 results for NTX1088 with Keytruda show preliminary anti-tumor activity and tolerability.

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