Neurocrine Reports Clinically Meaningful Benefits in 94% of Patients Treated for Tardive Dyskinesia

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Neurocrine Biosciences presented new data showing that valbenazine, sold as INGREZZA, delivered clinically meaningful benefits to 94% of patients over 48 weeks of treatment for tardive dyskinesia. The findings come from a post-hoc analysis of the Phase 3 KINECT-4 trial, where 59% of patients had previously achieved remission based on the strictest definition. Among those who did not meet that threshold, 86% still achieved at least a 30% reduction in Abnormal Involuntary Movement Scale score and 67% achieved at least a 50% reduction, bringing the combined meaningful-benefit figure to 94%. The company also presented a retrospective analysis of over 176,000 Medicare patients newly diagnosed with tardive dyskinesia, finding that 90% had at least one liver-related risk factor and 44% had three or more, including conditions like type 2 diabetes, hypertension, obesity, and hyperlipidemia.

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New data shows valbenazine (INGREZZA) delivers clinically meaningful benefits in 94% of tardive dyskinesia patients over 48 weeks.

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