Novartis Exercises Option to Acquire Sironax Brain Delivery Platform for $125 Million

M&A · PartnershipProduct / Tech
โดย GlobeNewswire·US·Read original
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Novartis has exercised its exclusive option to acquire the full global rights to Sironax's proprietary brain delivery platform, following the option and asset purchase agreement announced in July 2025. Under the terms of the option exercise agreement, Sironax will receive $125 million following the closing of the transaction, and the company will retain rights to develop, manufacture, and commercialize selected assets using the platform. Sironax said the proceeds will support three clinical-stage programs currently in Phase 1b/2, including SIR2501, a first-in-class allosteric inhibitor of SARM1 for ALS and chemotherapy-induced peripheral neuropathy that has received Fast Track designation from the FDA, along with SIR4156, an allosteric and globally first-in-class NAMPT activator for metabolic dysfunction, and SIR9900, a highly selective, brain-penetrant allosteric RIPK1 inhibitor for inflammatory and immunological diseases. The platform comprises proprietary brain delivery modules engineered to potentially enable in vivo transport of monoclonal antibodies, peptides, proteins, gene therapies, and other large biologics across the blood-brain barrier. Dr. Shefali Agarwal, President and CEO of Sironax, called the acquisition a major milestone that validates the company's science and technology.

Impact on stocks 1

Biotech & Genomic Medicine▲ · 1 stocks
Novartis AG
NOVN
▲ PositiveCapitalrelevance

Novartis exercised its option to acquire Sironax's brain delivery platform for $125 million, expanding its neurology pipeline via M&A.

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Off-coverage companies 1

Sironax USA, Inc.Private▲ Positive
Capitalrelevance

Sironax will receive $125 million and retains rights to develop selected assets, funding its three clinical-stage programs.

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