Revolution Medicines IncRevolution Medicines is a key player with candidate Daraxonrasib, which received FDA Breakthrough Therapy Designation.
A new competitive landscape report from DelveInsight reveals that more than 80 active pharmaceutical companies are developing over 90 pipeline molecular glues, with approximately 7 therapies in late-stage development and 15 in mid- or early-stage trials. Key players include Revolution Medicines, Gluetacs Therapeutics, Captor Therapeutics, Nurix Therapeutics, Monte Rosa Therapeutics, and Neomorph, among others, evaluating candidates such as Daraxonrasib, GT919, CT-01, and NEO-811. The report highlights notable mechanisms of action including RAS(ON) inhibition, GSPT1 degradation, and c-Myc degradation, and covers recent milestones like the FDA’s Breakthrough Therapy Designation for Daraxonrasib and the first patient dosing in Degron Therapeutics’ Phase 1 trial of DEG6498. Approved molecular glues POMALYST and REVLIMID from Bristol Myers Squibb are also profiled, underscoring the class’s established role in multiple myeloma and other hematologic malignancies.
Revolution Medicines IncRevolution Medicines is a key player with candidate Daraxonrasib, which received FDA Breakthrough Therapy Designation.
Monte Rosa Therapeutics IncMonte Rosa Therapeutics is listed as a key player with pipeline candidate NEO-811 in development.
Nurix Therapeutics IncNurix Therapeutics is listed as a key player in the molecular glue pipeline.
Bristol-Myers Squibb CompanyBristol Myers Squibb's approved molecular glues POMALYST and REVLIMID are profiled, highlighting their established role in multiple myeloma.
Affiliated Managers Group, Inc.Captor Therapeutics is named as a key player in the molecular glue pipeline, with its candidate CT-01 mentioned.
Gluetacs Therapeutics is listed as a key player with candidate GT919 in the pipeline.
Neomorph is named as a key player in the molecular glue landscape.
Degron Therapeutics dosed first patient in Phase 1 trial of DEG6498, a milestone.