Over 80 Companies Advance 90-Plus Molecular Glue Therapies in Global Pipeline

Industry
โดย GlobeNewswire·Read original
Summary · why it matters

A new competitive landscape report from DelveInsight reveals that more than 80 active pharmaceutical companies are developing over 90 pipeline molecular glues, with approximately 7 therapies in late-stage development and 15 in mid- or early-stage trials. Key players include Revolution Medicines, Gluetacs Therapeutics, Captor Therapeutics, Nurix Therapeutics, Monte Rosa Therapeutics, and Neomorph, among others, evaluating candidates such as Daraxonrasib, GT919, CT-01, and NEO-811. The report highlights notable mechanisms of action including RAS(ON) inhibition, GSPT1 degradation, and c-Myc degradation, and covers recent milestones like the FDA’s Breakthrough Therapy Designation for Daraxonrasib and the first patient dosing in Degron Therapeutics’ Phase 1 trial of DEG6498. Approved molecular glues POMALYST and REVLIMID from Bristol Myers Squibb are also profiled, underscoring the class’s established role in multiple myeloma and other hematologic malignancies.

Impact on stocks 5

Biotech & Genomic Medicine · 4 stocks
Revolution Medicines Inc
RVMD
▲ PositiveTechnologyrelevance

Revolution Medicines is a key player with candidate Daraxonrasib, which received FDA Breakthrough Therapy Designation.

Monte Rosa Therapeutics Inc
GLUE
▲ PositiveTechnologyrelevance

Monte Rosa Therapeutics is listed as a key player with pipeline candidate NEO-811 in development.

Bristol-Myers Squibb Company
BMY
▲ PositiveTechnologyrelevance

Bristol Myers Squibb's approved molecular glues POMALYST and REVLIMID are profiled, highlighting their established role in multiple myeloma.

Financials · 1 stocks

Theme Impact 1

Off-coverage companies 4

Captor Therapeutics S.A.Private▲ Positive
Technologyrelevance

Captor Therapeutics is named as a key player in the molecular glue pipeline, with its candidate CT-01 mentioned.

Gluetacs Therapeutics (Shanghai) Co., Ltd.Private▲ Positive
Technologyrelevance

Gluetacs Therapeutics is listed as a key player with candidate GT919 in the pipeline.

Neomorph, Inc.Private▲ Positive
Technologyrelevance

Neomorph is named as a key player in the molecular glue landscape.

Degron TherapeuticsPrivate▲ Positive
Technologyrelevance

Degron Therapeutics dosed first patient in Phase 1 trial of DEG6498, a milestone.

Related news

UBS Flags AI Science Shift as Investment Theme After OpenAI Proof

UBS Wealth Management says artificial intelligence is moving beyond text generation into scientific research, opening investment opportunities across AI infrastructure, pharmaceuticals, nuclear fusion, industrial materials and utilities. The shift was highlighted by OpenAI's recent mathematical proof related to the Navier-Stokes equations, a centuries-old fluid dynamics problem and one of seven Millennium Prize Problems, which OpenAI tackled using 10,000 autonomous AI agents working in parallel for 88 hours before formalizing the proof with Lean, a system for machine-checked mathematical validation. In pharmaceuticals, multi-agent AI systems can simulate millions of protein variations in the cloud, and more than 170 AI-designed programs are already in development or clinical evaluation, including Phase III trials. In nuclear fusion, reinforcement-learning systems can predict plasma disruptions around 200 milliseconds before they occur and adjust magnetic coils thousands of times per second, while AI models in materials science can test millions of elemental combinations daily in search of properties for lighter, higher-density batteries, lower-heat computing hardware and potential room-temperature superconductors. The broader investment case centers on AI becoming a tool for automating scientific research rather than simply generating content, with companies exposed to AI infrastructure, pharmaceuticals, industrial materials and utilities positioned to benefit as these technologies move toward commercial applications.
Investing.com·7hRead more →

NAVER D2SF Backs ImpriMed in $10 Million Series A2 Bridge Round

NAVER D2SF, NAVER's in-house corporate venture arm, has invested in Silicon Valley precision medicine company ImpriMed, joining ImpriMed's $10 million Series A2 bridge round. The round was led by LB Investment, with participation from new investors NAVER D2SF, Samsung Securities, and Alois Ventures, plus follow-on investments from existing investors BonAngels and Han River Partners; it follows ImpriMed's $23 million Series A in 2023. ImpriMed combines ex vivo analysis of patient-derived live cancer cells with genomic, immunophenotypic, and clinical data through its xCellSense platform, and is developing AI models trained on more than 3.5 million data points. The company is preparing to commercialize products for blood cancers and blood infection, targeting FDA clearance and CLIA certification by Q1 2027 for an initial U.S. launch, while in South Korea its multiple myeloma prognosis and therapy-response software has been designated an Innovative Medical Device by the Ministry of Food and Drug Safety. ImpriMed was co-founded by CEO Sungwon Lim and CTO Jamin Koo, and its human healthcare expansion is supported by veterinary precision oncology work covering more than 27,000 tests for canine and feline lymphoma, used by over 600 veterinary hospitals across the United States, Canada, the United Kingdom, France, and South Korea.
PR Newswire·17hRead more →

Anthropic Establishes Biology Research Lab to Pursue AI-Driven Drug Development

US artificial intelligence developer Anthropic has established a biology research institute as it moves toward full-scale drug development using AI technology. According to two people familiar with the matter, the company has opened a wet lab experimental facility in the San Francisco Bay Area, aiming to develop treatments for rare diseases, and its biological research goes beyond the realm of computer simulation. Eric Kauderer-Abrams, head of the life sciences division, confirmed to Reuters on the 15th that the company operates a wet lab, saying its mission is to develop powerful AI that benefits the world, and that it sees the greatest potential especially in the life sciences field. A public relations representative later explained that the institute is not specifically aimed at drug discovery, but declined to comment further. Kauderer-Abrams said efforts to use AI to automate the execution of experimental work are still in their early stages, but could bring significant reductions in working time across many different processes, and that the company is approaching how to use it carefully and thoughtfully in order to improve its models and minimize risk in ways that facilitate and accelerate drug development. The diseases Anthropic is working to develop treatments for, and its progress, remain unclear.
ロイター·22hRead more →