Roivant's Mosliciguat Cuts Pulmonary Vascular Resistance 56.3% in Phase 2 Trial

Product / TechAnalyst Impact 4
โดย Insider Monkey·US·Read original
Summary · why it matters

Roivant Sciences shares surged 18% on September 8 after the biotech reported positive topline Phase 2 results for mosliciguat, an experimental treatment for pulmonary hypertension. In the PHocus trial, the drug produced a 56.3% placebo-adjusted reduction in pulmonary vascular resistance in patients with pulmonary hypertension associated with interstitial lung disease, well above the 20% threshold Leerink Partners analyst David Risinger had flagged as an important benchmark, along with a 35.2-meter placebo-adjusted improvement in six-minute walk distance at Week 16. Risinger said mosliciguat could potentially generate more than $10 billion in annual sales across multiple indications, a distinction that matters for Roivant's long-term growth strategy as it seeks to reduce reliance on a small number of products; Roivant has already secured U.S. approval for Lisraya. The company still must complete its Phase 3 PHrontier trial and show the benefits can be reproduced, and a disappointing late-stage result could trigger a significant valuation reset after the sharp post-results rally. Hedge fund holdings in Roivant rose to 64 in the second quarter from 60 in the first, though positioning was mixed, with QVT Financial cutting its exposure by 6% to approximately $839.6 million and Farallon Capital raising its stake by 48% to approximately $506.4 million.

Impact on stocks 4

Biotech & Genomic Medicine▲ · 1 stocks
Roivant Sciences Ltd
ROIV
▲ PositiveTechnologyrelevance

Mosliciguat produced a 56.3% placebo-adjusted reduction in pulmonary vascular resistance in the Phase 2 PHocus trial, a positive clinical readout for Roivant.

Aging Population▲ · 1 stocks
Artificial Intelligence▲ · 1 stocks
Energy Transition & Power Demand▲ · 1 stocks

Theme Impact 1

Off-coverage companies 3

Farallon Capital ManagementPrivate± Mixed
relevance

Leerink PartnersPrivate± Mixed
relevance

QVT FinancialPrivate± Mixed
relevance

Related news

▲

Amgen Fair Value Target Rises to US$388.03 as Analysts Split on Pipeline Risks

Amgen's updated analyst model lifted its fair value price target to US$388.03 from a prior US$371.93, with the revenue growth assumption rising to 3.50% from 2.93%, the net profit margin assumption moving to 25.15% from 24.84%, the future P/E multiple changing to 25.1x from 24.6x, and the discount rate shifting to 7.96% from 7.70%. The revision reflects a split analyst view, with UBS, Argus, TD Cowen, Scotiabank and Oppenheimer raising their Amgen price targets into a US$420 to US$460 range on the strength of a strong product portfolio, Q2 beats and higher guidance. Wells Fargo and Piper Sandler lifted their targets to US$435, citing external survey work and prescription data they believe support higher long term sales potential for cholesterol and cardiovascular products such as Repatha and Lipfendra. On the bearish side, HSBC downgraded Amgen to Hold and cut its target to US$425 from US$445, saying the stock price now more closely matches its assessment of fair value with limited near term upside, while BMO Capital shifted to a neutral Market Perform stance even with a higher US$450 target, citing ongoing loss of exclusivity headwinds and a need for more clarity on the competitive profile and sales potential of MariTide.
AMGN ▲
Biotech & Genomic Medicine
Simply Wall St·10hRead more →
▲

Edwards Lifesciences Targets $2 Billion TMTT Business by 2030 as CMS Expands TAVR Access

Edwards Lifesciences outlined a structural heart growth plan that targets more than US$2 billion in transcatheter mitral and tricuspid revenue by 2030, anchored by its PASCAL, EVOQUE, and Sapien M3 technologies. The plan sits alongside updated Medicare coverage that could enable 100 to 200 additional U.S. centers to perform TAVR procedures, reinforcing the company's transcatheter ecosystem. Edwards' broader narrative projects $8.5 billion in revenue and $2.2 billion in earnings by 2029, requiring 9.3% yearly revenue growth and an earnings increase of about $1.2 billion from $979.9 million today. Three fair value estimates from the Simply Wall St Community cluster between US$91.47 and US$100.96 per share, against a $100.96 fair value that implies 14% upside to the current price. The company still faces risks around margins, tariffs, and competitive pressure in international markets.
EW ▲
Biotech & Genomic Medicine ▲
Simply Wall St·14hRead more →
▼impact 4

Novartis Shares Plunge 10% as Del-desiran Fails Late-Stage Trial

Novartis shares fell about 10% after the company said its experimental drug del-desiran failed to meet its primary goal in a late-stage trial for myotonic dystrophy type 1, marking its third clinical setback in a week. The earlier failures involved the cardiovascular drug pelacarsen and a pause of eight trials of the cell therapy rap-cel following three patient deaths. The decline erased roughly 24 billion Swiss francs, or about $29.6 billion, in market value and put Novartis on pace for one of its worst trading days in company history. Barclays had estimated peak annual sales of about $3.1 billion for del-desiran and assigned the drug a 60% probability of success after positive mid-stage results, and the failure raises questions about the $12 billion Avidity acquisition that brought the drug into Novartis' pipeline. Management reaffirmed its full-year financial guidance and maintained its target for 5% to 6% compound annual sales growth from 2025 through 2030, while the company reported successful late-stage results for remibrutinib in multiple sclerosis and expects more data later this year.
NOVN.SW ▼
Biotech & Genomic Medicine ▼
CNBC·1dRead more →
© 2026 MarketDXNews