Aclaris Therapeutics, Inc. is a clinical-stage biopharmaceutical company that discovers and develops novel molecule product candidates for immuno-inflammatory diseases in the United States. Its pipeline includes Bosakitug (ATI-045), an anti-thymic stromal lymphopoietin monoclonal antibody in Phase 2 trials for moderate to severe atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyps, and moderate to severe chronic obstructive pulmonary disease; ATI-2138, a potent and selective investigational dual inhibitor of ITK and JAK3 in Phase 2a trials for T cell-mediated autoimmune diseases; ATI-052, a humanized anti-TSLP and anti-IL4R bispecific antibody in Phase 1b for various atopic, immunologic, and respiratory diseases; ATI-9494, an oral, covalent, investigational dual inhibitor of ITK and Resting Lymphocyte Kinase (TXK), and other covalent JAK-sparing ITK inhibitors to modulate T cell biology across various diseases; and Lepzacitinib, a soft JAK 1/3 inhibitor for atopic dermatitis and other dermatologic conditions. The company was incorporated in 2012 and is headquartered in Wayne, Pennsylvania.