Editas Medicine, Inc. is a clinical-stage genome editing company focused on developing genomic medicines for serious diseases. Its proprietary platform is based on CRISPR technology. The lead program, EDIT-401, is a one-time therapy designed to lower LDL cholesterol by upregulating the LDL receptor to treat hyperlipidemia. The company also develops therapies for sickle cell disease and transfusion-dependent beta thalassemia, as well as in vivo gene editing medicines for other cells and tissues. It has a research collaboration with Juno Therapeutics, Inc. to develop alpha-beta T-cell experimental medicines for solid and liquid tumors and autoimmune disease. Formerly known as Gengine, Inc., it changed its name to Editas Medicine, Inc. in November 2013. Incorporated in 2013, the company is based in Cambridge, Massachusetts.