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Simcere Pharmaceutical Group Ltd

Simcere Pharmaceutical Group Limited, an investment holding company, engages in the research, development, manufacture, and sale of pharmaceutical products to distributors, pharmacy chains, and other pharmaceutical manufacturers in China. It develops Endostar, a recombinant human endostatin injection; ENWEIDA, an envafolimab injection; Leruiping, a fully human monoclonal antibody targeting IL-4Ra; Zemprocitinib a highly selective JAK1 inhibitor; and Xianlinda, an inhibitor for influenza polymerase acidic protein that has completed Phase 3 clinical trials. The company also develops SIM0270, a new-generation oral SERD with blood-brain barrier penetration characteristics; Denlorlatinib; SIM0395, a BBB-penetrant inhibitor of the PI3K/mTOR pathway; and deuterated remdesivir hydrobromide dry suspension that are in Phase 3 clinical trial, as well as Sanbexin an injection new indication; Sanbexin a sublingual tablets; and SIM0278, a Fc fusion protein (IL2muFc) with an IL2 mutein of regulatory T cells that is in Phase 2 clinical trials. It develops SIM0237, an anti-PD-L1 monoclonal antibody fused with IL-15/IL15RXa sushi protein; Enzeshu, a suvemcitug for injection; SIM0500, a humanized trispecific antibody that targets GPRC5D/BCMA/CD3; SIM0508, a small molecule inhibitor; SIM0505, a CDH6-targeting ADC molecule; SIM0686, an ADC drug targeting FGFR2b; SIM0609, a new antibody-drug conjugate targeting CDH17; SIM0610, a bispecific antibody-drug conjugate; SIM0532, an oral, non-covalent pan-RAS inhibitor; SIM0323; and SIM0811, a small-molecule plasminogen allosteric activator that are in Phase 1 clinical trial. The company develops SIM0613; SIM0709; SIM0689; SIM0688; SIM0518; SIM0616; SIM0611; SIM0815; SIM0712; SIM0725; SIM0708; SIM0721; and SIM0722 that are in pre-clinical stage. It offers pharmaceutical ingredients; production support facility; consulting and technology; promotion; and property management. The company was founded in 1995 and is headquartered in Nanjing, China.

Price · split & dividend adjusted
News & notes moving 2096.HK
Biotech & Genomic Medicine

COVID-19 drugs hard to find at brick-and-mortar pharmacies as manufacturers activate emergency production

The positive rate for COVID-19 tests has recently climbed to 20.3%, driving up market demand for antiviral drugs. Yet physical pharmacies are widely out of stock, with some staff even recommending anti-flu medications such as oseltamivir and baloxavir marboxil. Six domestically developed oral COVID-19 treatments have now been approved in China, including Genuine Biotech’s Jiebeian, Simcere Pharmaceutical’s Xiannuoxin, Junshi Biosciences’ Mindewei, Zonsen Pharmaceutical’s Leruiling, Cosunter’s Taizhongding, and Aisen Pharmaceutical’s Aoweining. However, multiple pharmacies reported that none of these drugs appeared in their inventories. Online platforms, by contrast, all have them available. Data from JD Pharmacy shows that transaction volumes for COVID-19 medications in July rose nearly fourfold month on month. Faced with surging demand, Simcere Pharmaceutical said it has activated an emergency production mechanism. Cosunter noted that sales of Taizhongding have increased and it will broaden hospital coverage. Junshi Biosciences has also launched an emergency plan to ensure supply. Industry insiders point out that earlier regulatory restrictions confined COVID-19 drugs mainly to hospitals and online sales, and they are calling for a reassessment of retail channel controls.
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