Biotech & Genomic Medicine▲
Five Biotech Stocks Deliver Big Gains With Key Catalysts Ahead
Five biotech stocks featured on RTTNews have delivered substantial gains, with upcoming catalysts that could drive further upside. uniQure N.V. surged 186% since August 2025, driven by positive data for its Huntington's disease gene therapy AMT-130, and is on track to submit regulatory filings in the third quarter of 2026. CareDx Inc. gained 138% since June 2025 after a series of strong earnings reports, raised guidance, and the acquisition of Naveris, with the commercial launch of the NavDx liquid biopsy test as a key catalyst. Adaptive Biotechnologies Corp. rose 130% since May 2025, supported by growing adoption of its clonoSEQ MRD test and multiple guidance raises, with the planned separation of its Immune Medicine business as a potential catalyst. Enliven Therapeutics Inc. jumped 207% since November 2025 on positive Phase 1 data for its chronic myeloid leukemia drug ELVN-001, and expects to initiate a Phase 3 trial in the second half of 2026. Amylyx Pharmaceuticals Inc. climbed 217% since June 2025, with a pivotal Phase 3 data readout for its post-bariatric hypoglycemia drug Avexitide anticipated in the third quarter of 2026.
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Biotech & Genomic Medicine▼
Adaptive Biotechnologies Q2 net loss widens to $39.94 million despite 22% revenue growth
Adaptive Biotechnologies reported a wider second-quarter net loss even as revenue grew 22%. Net loss expanded to $39.94 million, or $0.25 per share, from $25.59 million, or $0.17 per share, a year earlier. Revenue rose to $71.6 million from $58.88 million, driven by a 33% increase in its Minimal Residual Disease segment to $66.16 million, while Immune Medicine revenue fell 40% to $5.38 million. The company raised its full-year 2026 MRD revenue guidance to between $268 million and $278 million, up from the prior range of $260 million to $270 million. Shares fell over 5% in overnight trading following the announcement.
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ADPT
Adaptive Biotechnologies CSO Sells $8.5 Million in Stock After 85% Run
Adaptive Biotechnologies Chief Scientific Officer Harlan S. Robins sold 386,240 shares at $22.01 per share on July 2, 2026, for a total of $8.5 million. The sale was executed under a Rule 10b5-1 trading plan adopted on March 13, 2026, and Robins still directly holds 1,019,658 shares worth approximately $21.61 million. The stock had returned 85% over the prior year as of the transaction date, and the company recently reported first-quarter revenue up 35% to $70.9 million, driven by its clonoSEQ MRD test, while narrowing its net loss to $20 million.
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Biotech & Genomic Medicine▲
Imviva Biotech Receives FDA IDE Authorization for clonoSEQ Assay in TENACITY-01 Trial
Imviva Biotech has received FDA Investigational Device Exemption authorization for Adaptive Biotechnologies' clonoSEQ assay in the TENACITY-01 clinical trial. The assay will identify patients with T-cell malignancies who have minimal residual disease levels of 0.1% or higher for enrollment and will detect and quantify MRD in post-treatment bone marrow samples to support exploratory analyses. The trial evaluates CTD402, Imviva's investigational allogeneic anti-CD7 CAR-T cell therapy, in relapsed/refractory T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and MRD-positive patients in first or second complete remission. The global, single-arm, open-label study plans to enroll up to 120 patients divided between relapsed/refractory and MRD-positive cohorts, with all participants receiving a standard lymphodepletion regimen and a flat dose of 400×10⁶ CTD402 CAR-T cells. IDE authorization confirms the assay can be used in a highly regulated clinical development program where test results may guide patient management.
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Biotech & Genomic Medicine▲
BTIG Maintains Buy Rating on Adaptive Biotechnologies with $22 Target
BTIG maintained a Buy rating on Adaptive Biotechnologies with a $22 price target following two company announcements. Adaptive upsized its convertible notes offering to $300 million from the originally planned $250 million and revealed plans to separate its MRD and immune medicine businesses. BTIG views both moves positively, considering the immune medicine unit non-core and believing the spin-off will unlock greater value in the core MRD business. The firm noted that while shares dipped slightly due to technical nuances around the offering, discussions with management reassured them that the announcements reflect a position of strength with strong momentum across all MRD applications.
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ADPT
Adaptive Biotechnologies Prices Upsized $300 Million Convertible Senior Notes Offering
Adaptive Biotechnologies Corporation has priced an upsized private offering of $300 million in 0% convertible senior notes due 2031, increasing the deal from the previously announced $250 million. The notes, which carry no regular interest and do not accrete, have an initial conversion price of approximately $24.11 per share, a 40% premium over the last reported sale price of $17.22 on June 16, 2026. Net proceeds are estimated at $290.8 million, with roughly $22.3 million allocated to capped call transactions, $25 million to repurchase 1,451,800 shares of common stock, and the remainder directed toward repaying the OrbiMed Purchase Agreement, general corporate purposes, and opportunistic initiatives in the MRD business. The company also granted initial purchasers a 13-day option to buy up to an additional $45 million in notes, which would bring total net proceeds to approximately $334.5 million if fully exercised. The capped call transactions have an initial cap price of $34.44 per share, representing a 100% premium, and are designed to reduce potential dilution upon conversion.
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