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Aligos Therapeutics Inc

Aligos Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the development of novel therapeutics to address unmet medical needs in liver and viral diseases. Its drug candidate, ALG-055009, a small molecule THR-ß agonist that is in the Phase 2a clinical trial for the treatment of metabolic dysfunction-associated steatohepatitis and obesity. The company also develops pevifoscorvir sodium, a capsid assembly modulator, which is in Phase 2 B clinical trial; and ALG-097558, a small molecule ritonavir-free pan-coronavirus protease inhibitor which has completed a Phase 1 clinical trial for the treatment of coronavirus. The company has entered into license and research collaboration agreement with Emory University; and Katholieke Universiteit Leuven. Aligos Therapeutics, Inc. was incorporated in 2018 and is headquartered in South San Francisco, California.

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Biotech & Genomic Medicine

Aligos Secures $25M Upfront in Greater China HBV Deal

Aligos Therapeutics has received a $25 million upfront payment from Xiamen Amoytop Biotech under an exclusive license agreement for Pevifoscorvir sodium in Greater China. The therapy targets chronic hepatitis B virus infection and recently obtained Breakthrough Therapy Designation from China's National Medical Products Administration. Aligos is eligible for up to $420 million in clinical, regulatory, and sales milestones, plus tiered royalties on net sales in Amoytop's licensed territories, while retaining rights in the U.S., Europe, South Korea, Japan, and other markets. CEO Lawrence Blatt noted that a joint steering committee has been formed and Amoytop plans to initiate clinical development of Aligos' antisense oligonucleotide candidate ALG-170675 in China later this year. The stock closed Monday at $5.85, up 4.65%, and rose to $6.46 in overnight trading, a 10.43% gain.
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