DSS, Inc. operates in product packaging, biotechnology, commercial lending, securities and investment management, and direct marketing in the United States. It manufactures and sells mailers, photo sleeves, custom folding cartons, and 3D direct mail solutions, and markets nutritional and personal care products. The company invests in or acquires biohealth and biomedical businesses, including drug discovery and prevention, inhibition, and treatment of neurological, oncological, and immune-related diseases, and develops open-air defense initiatives for airborne infectious diseases such as tuberculosis and influenza. It also acquires equity positions in undervalued commercial banks, bank holding companies, and nonbank licensed financial companies, provides securities and investment management services, operates a real estate investment trust for hospitals and acute or post-acute care centers, and develops assets in securities trading and funds management. The company was formerly known as Document Security Systems, Inc. and changed its name to DSS, Inc. in September 2021. DSS, Inc. was incorporated in 1984 and is headquartered in West Henrietta, New York.