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Enanta Pharmaceuticals Inc

Enanta Pharmaceuticals, Inc. is a biotechnology company that discovers and develops small molecule drugs for virology and immunology indications. Its pipeline includes EDP-514 in Phase 1b for chronic hepatitis B virus (HBV); zelicapavir and EDP-323 in Phase II for respiratory syncytial virus; EDP-235 in Phase II for human coronaviruses; EDP-978 for chronic spontaneous urticaria (CSU); glecaprevir, an antiviral protease inhibitor for chronic hepatitis C virus (HCV); and EPS-3903 for atopic dermatitis. The company has a collaborative development and license agreement with Abbott Laboratories to develop, manufacture, and commercialize HCV NS3 and NS3/4A protease inhibitor compounds, including paritaprevir and glecaprevir. Incorporated in 1995, Enanta is headquartered in Watertown, Massachusetts.

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Biotech & Genomic Medicine

Enanta Pharmaceuticals shares rise 5.2% after AbbVie's Maviret wins European approval

Enanta Pharmaceuticals shares rallied 5.2% to close at $14.06 after partner AbbVie received European Commission approval for Maviret to treat acute hepatitis C virus infection in adults and children aged three years and above. Glecaprevir, one of the two direct-acting antiviral components of Maviret, was discovered by Enanta and is developed and commercialized by AbbVie, from which Enanta receives royalties on net sales. The move came on notable volume and compares to a 4.2% loss over the past four weeks. Enanta is expected to report a quarterly loss of $0.37 per share on revenues of $18.17 million.
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ENTA

Appeals court upholds Pfizer patent win against Enanta over Paxlovid

A federal appeals court has upheld a lower court ruling in favor of Pfizer in a patent dispute with Enanta Pharmaceuticals over the COVID-19 therapy Paxlovid. The Court of Appeals for the Federal Circuit affirmed a summary judgment that U.S. Patent No. 11,358,953, which covers coronavirus protease inhibitors, is invalid. Enanta had filed suit in 2022 seeking damages, alleging Pfizer infringed the patent during Paxlovid's development and commercialization. The U.S. District Court for the District of Massachusetts ruled in December 2024 that the patent was invalid, prompting Enanta's appeal.
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Biotech & Genomic Medicine

AbbVie Wins European Approval for MAVIRET to Treat Acute Hepatitis C

The European Commission has approved AbbVie's MAVIRET for the treatment of acute hepatitis C virus infection, making it the only therapy cleared in the European Union for both acute and chronic HCV. The approval was supported by a Phase 3 study in which 96.2% of patients achieved sustained virological response 12 weeks post-treatment. MAVIRET combines glecaprevir, discovered by Enanta Pharmaceuticals, and pibrentasvir, and is already approved for chronic HCV. Enanta earns royalties on AbbVie's sales of the drug, which is sold as MAVYRET in the U.S. and MAVIRET elsewhere.
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