Lantheus Holdings, Inc. develops, manufactures, and commercializes diagnostic and therapeutic products that assist clinicians in diagnosis and treatment of heart, cancer, and other diseases worldwide. The company offers DEFINITY, an injectable ultrasound enhancing agent used in echocardiography exams; TechneLite, a technetium generator for nuclear medicine procedures; Xenon-133, a radiopharmaceutical gas to assess pulmonary function; Neurolite, an injectable imaging agent to identify the area within the brain where blood flow has been blocked or reduced due to stroke; Cardiolite, an injectable Tc-99m-labeled imaging agent to assess blood flow to the muscle of the heart; and PYLARIFY, an F 18-labelled PSMA-targeted PET imaging agent used for imaging of PSMA positive-lesions in men with prostate cancer. It also provides Automated Bone Scan Index that calculates the disease burden of prostate cancer by detecting and classifying bone scan tracer uptakes as metastatic or benign lesions using an artificial neural network; RELISTOR for opioid-induced constipation; and aPROMISE, an artificial intelligence medical device software; PYLARIFY AI, an medical device software to perform quantitative assessment of PSMA PET/CT images in prostate cancer; and flurpiridaz used to assess blood flow to the heart. In addition, it develops PNT2002, a radiopharmaceutical therapy to treat mCRPC; PNT2003, an SSTR therapy to patients with SSTR-positive neuroendocrine tumors; MK-6240, a F 18-labeled PET imaging agent for Tau tangles in Alzheimer's disease; LNTH-2401, a novel radiodiagnostic targeting the gastrin-releasing peptide receptor; LNTH-2402; LNTH-2403; LNTH-2404; LNTH-250; LNTH-2515; and LNTH-1363S, an fibroblast activation protein, alpha, copper-64 labeled PET imaging agent. It has collaboration agreements with GE Healthcare; Curium Pharma; POINT; Regeneron; and Ratio Therapeutics LLC. The company was founded in 1956 and is based in Bedford, Massachusetts.
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Biotech & Genomic Medicine▲
Lantheus wins FDA approval for Tauklarify tau PET imaging agent
Lantheus Holdings announced on Friday that the FDA has approved Tauklarify, a radiodiagnostic agent for detecting tau pathology in the brain of adults with Alzheimer’s disease using positron emission tomography. The approval covers use in cognitively impaired adults being evaluated for Alzheimer’s to determine whether tau neurofibrillary tangle pathology is present. The company said tau PET imaging complements amyloid PET and other diagnostic tools, and the approval is supported by data from two studies involving more than 500 patients who received a single intravenous dose. Lantheus CEO Mary Anne noted that clinicians are seeking a more complete understanding of the disease as the field advances.
Key M&A deals this week include DoubleVerify, AMD, Visa, Prologis
Several major acquisition agreements were announced this week. DoubleVerify agreed to be acquired by Nielsen in an all-cash transaction valued at approximately $2.15 billion, with shareholders receiving $13.60 per share. Advanced Micro Devices signed a definitive agreement to acquire Taalas, a developer of specialized AI inference silicon. Visa agreed to acquire BioCatch, a provider of behavioral-first fraud intelligence, for $2.4 billion from funds advised by Permira. Prologis reached an agreement to buy SEGRO plc for about $18.8 billion after securing a board recommendation. Bending Spoons is acquiring Airtable in an all-cash transaction valuing the workflow software company at an enterprise value of $1.285 billion, implying an equity value of about $2.25 billion. Curium announced a deal to acquire all outstanding shares of Lantheus Holdings for up to $114.50 per share in cash, including contingent value rights. Atkore entered into a definitive agreement to be acquired by Prysmian in an all-cash transaction representing an enterprise value of approximately $3.8 billion. Supernus Pharmaceuticals and Indivior Pharmaceuticals agreed to merge in an all-stock merger of equals. Digital Brands Group shares surged after receiving a proposal from an existing shareholder to acquire all outstanding shares for $77.58 per share in cash. Gloo entered into a definitive agreement to acquire Cedarstone, a business services firm serving nonprofit organizations.
Halper Sadeh LLC, an investor rights law firm, is investigating whether MarketAxess Holdings, Sanara MedTech, and Lantheus Holdings are obtaining fair deals for their shareholders in proposed acquisitions. The firm is examining MarketAxess Holdings' sale to Intercontinental Exchange for $167.00 per share in cash, Sanara MedTech's sale to MiMedx Group for $33.00 in cash and 0.4735 shares of MiMedx common stock per Sanara share, and Lantheus Holdings' sale to Curium US Holdings for $102.50 per share in cash plus non-transferable Contingent Value Rights providing up to $12.00 per share in potential additional cash payments tied to commercial milestones through 2030. Halper Sadeh LLC may seek increased consideration, additional disclosures, or other relief on behalf of shareholders, and encourages affected investors to contact the firm at no cost to discuss their legal rights and options.
Curium to acquire Lantheus in all-cash deal worth up to $8 billion
CapVest Partners-backed Curium has agreed to buy rival US-based radiopharmaceutical company Lantheus in an all-cash deal worth up to nearly $8 billion. Under the agreement, Curium US will purchase all outstanding shares of Lantheus for $102.50 per share upon closing, with shareholders also set to receive non-transferable contingent value rights that could provide up to an additional $12.00 per share if certain commercial milestones are met by 2030, bringing the potential total consideration per share to $114.50. The offer represents a 38% premium to Lantheus' 60-day volume-weighted average price and a 21% premium above its closing price as of 21 May 2026, the last day before media reports emerged about the potential sale. The proposed transaction has received unanimous approval from Lantheus' Board of Directors and is expected to close in the first half of 2027, subject to regulatory and shareholder approvals, with financing through a mix of debt and equity and no financial conditions attached.
Halper Sadeh LLC Investigates Lantheus, Atkore, and Indivior Deals for Shareholder Fairness
Halper Sadeh LLC, an investor rights law firm, is investigating whether the proposed sales of Lantheus Holdings, Atkore, and Indivior Pharmaceuticals are obtaining fair deals for their shareholders. The firm is examining Lantheus Holdings' sale to Curium US Holdings for $102.50 per share in cash plus non-transferable Contingent Value Rights providing up to $12.00 per share in potential additional cash payments, Atkore's sale to Prysmian for $95.00 per share in cash, and Indivior's merger with Supernus Pharmaceuticals in which Indivior shareholders would own approximately 56.5% of the combined company. Halper Sadeh LLC may seek increased consideration, additional disclosures, or other relief on behalf of shareholders, and encourages them to contact the firm to discuss their rights at no cost.
KKR nears Integer Holdings buyout, ICE to acquire MarketAxess in $6 billion deal
Several major deals were reported this week across sectors. KKR is close to a deal to take medical-device outsourcer Integer Holdings private, sending its shares up 20%. Intercontinental Exchange agreed to acquire fixed-income electronic trading platform MarketAxess Holdings in a transaction valuing its equity at roughly $6.0 billion and total enterprise at $5.7 billion. Grant Thornton Advisors agreed to buy professional services firm CBIZ in an all-cash deal with a $5 billion enterprise value, backed by New Mountain Capital. Koch Inc. is exploring a sale of data center developer Edged that could value it at more than $15 billion. KKR and Energy Capital Partners agreed to acquire Ireland-based energy distributor DCC Energy in a deal valued at about £5.7 billion, with shareholders receiving £65.25 per share in cash plus a final dividend and a potential contingent payment. TransDigm Group agreed to acquire Prince & Izant from Industrial Growth Partners for approximately $1.066 billion in cash. argenx SE will acquire Forte Biosciences for $77 per share in cash, a transaction valued at roughly $2.2 billion, adding a first-in-class anti-CD122 antibody to its immunology portfolio. Ambarella shares surged 19% on a report that NXP Semiconductors is in talks to acquire the chip designer, though a deal is not certain. Curium is in advanced talks to buy radiopharma company Lantheus Holdings for about $102 per share upfront plus $12.50 per share in contingent value rights.
Bristol-Myers Raises Full-Year Outlook as Cancer Drugs Drive Q2 Beat
Bristol-Myers Squibb lifted its full-year outlook after reporting better-than-expected second-quarter 2026 results driven by higher sales of its cancer therapies. The company posted approximately $13.0 billion in revenue, beating consensus by $1.23 billion, with its growth portfolio contributing $7.6 billion. Adjusted earnings per share rose about 40% year-over-year to $2.04, exceeding estimates by $0.44. Bristol-Myers now expects full-year revenue of about $49.0 billion to $50.0 billion and adjusted EPS of $6.75 to $7.00, up from prior guidance and ahead of consensus. In other healthcare news, Johnson & Johnson agreed to pay up to $5.5 billion to settle remaining talc lawsuits alleging its products caused ovarian cancer, conditioned on at least 95% participation by claimants. Curium is in advanced talks to acquire Lantheus Holdings for about $7 billion upfront, with an additional $12.50 per share in contingent value rights, potentially valuing the deal at $8 billion. Boston Scientific shares slipped after its full-year outlook trailed consensus, despite second-quarter revenue of $5.4 billion beating estimates. Most Medicare Part D enrollees will face higher premiums in 2027 after the Trump administration ended a subsidy program, with three out of four seeing increases. The S&P 500 Health Care Index Sector edged up 0.12% during the week.
Lantheus receives FDA Complete Response Letter for LNTH-2501
Lantheus has received a Complete Response Letter from the US Food and Drug Administration for LNTH-2501, its PET diagnostic imaging kit targeting somatostatin receptor-positive neuroendocrine tumors. The agency indicated the application cannot be approved due to ongoing issues at a third-party manufacturing site, though no issues were noted with the data supporting LNTH-2501. Lantheus CEO Mary Anne Heino stated the company is working closely with its partner and the FDA to address the facility manufacturing-related conditions and advance the program.
Healthcare Equipment and Supplies Stocks Post Mixed Q1 Results
Healthcare equipment and supplies stocks reported mixed first-quarter results, with the 37 companies tracked collectively beating revenue estimates by 2.3% but issuing next-quarter guidance 1.3% below expectations. Lantheus posted revenues of $377.3 million, up 1.2% year on year and exceeding estimates by 6.4%, though its full-year revenue guidance missed. STAAR Surgical delivered the strongest performance, with revenues surging 120% to $93.52 million and beating estimates by 20.8%, while Stryker was the weakest, reporting $6.02 billion in revenue that fell 5% short of expectations. Abbott Laboratories reported $11.16 billion in revenue, up 7.8% and beating estimates by 1.3%, and Integra LifeSciences posted $391.9 million, up 2.4% and exceeding estimates by 2.6%. On average, share prices across the group have declined 1.4% since the latest earnings results.