Nautilus Biotechnology, Inc. is a development-stage life sciences company that creates a platform technology for quantifying and unlocking the complexity of the proteome in the United States. It develops the Nautilus Voyager Platform, an end-to-end solution comprising instruments, reagents, consumables, and software analysis. The company also provides the Nautilus Voyager instrument, a high-resolution optical imaging system with integrated fluidics and liquid handling subsystems for depositing protein libraries onto a flow cell and processing labeled multi-affinity reagent binding and imaging cycles to decode and quantify proteins in biological samples. Additionally, it offers single-molecule library preparation kits, flow cells, affinity reagents, and instrument run buffers for multi-cycle analysis runs. Nautilus has research collaborations with Genentech, Buck Institute, Allen Institute, Cornell University, the Qatar Foundation, and the Michael J. Fox Foundation. Founded in 2016, the company is headquartered in Seattle, Washington.