Definium Stock Soars 50% as Phase III Depression Study Meets Key Goals

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Definium Therapeutics shares surged 49.8% after the company announced positive top-line results from its phase III Emerge study of DT120 orally disintegrating tablet in adults with major depressive disorder. The study met its primary endpoint, showing an 8.1-point placebo-adjusted reduction in depressive symptoms at week 6 as measured by the MADRS scale, and all key secondary endpoints were also met. At week 1, patients receiving a single 100 µg dose showed a 14.2-point placebo-adjusted improvement, with benefits sustained through week 12. Response rates at week 6 were 35% for DT120 versus 7% for placebo, and remission rates were 24% versus 3%. The treatment was generally well tolerated, with 99% of adverse events mild to moderate and no serious safety concerns.

Impact on stocks 4

Biotech & Genomic Medicine▲ · 2 stocks
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Definium Therapeutics, Inc.
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Positive Phase III results for DT120 in major depressive disorder, meeting primary and secondary endpoints.

Health Care▲ · 1 stocks

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