Moderna's mRNA Cancer Therapy Scores First Positive Phase III Readout

Product / TechRegulation Impact 4
โดย Zacks Investment Research·US·Read original
Summary · why it matters

Moderna and Merck reported positive results from the late-stage INTerpath-001 study of intismeran autogene (V940/mRNA-4157) in combination with Keytruda in patients with high-risk Stage IIB-IV melanoma whose tumors had been removed through surgery. The study met its primary endpoint of recurrence-free survival and a key secondary endpoint of distant metastasis-free survival, with the companies stating the improvements were statistically significant and clinically meaningful, though no numerical data were disclosed. INTerpath-001 marks the first positive phase III readout for an individualized neoantigen therapy and an mRNA-based cancer therapy, and five-year follow-up from the phase IIb KEYNOTE-942 study showed the combination reduced the risk of recurrence or death by 49% and the risk of distant metastasis or death by 59% versus Keytruda alone. Moderna and Merck are evaluating intismeran across nine phase II and phase III studies spanning multiple tumor types, including non-small cell lung cancer, bladder cancer and renal cell carcinoma, while Moderna's broader pipeline includes separate mRNA-based cancer antigen therapies, a T-cell engager and a cell-therapy enhancer. Moderna shares have skyrocketed nearly 400% year to date, outperforming the industry's 7% growth, and the stock trades at 23.44 times forward 12-month sales versus the industry average of 1.90 times.

Impact on stocks 5

Biotech & Genomic Medicine▲ · 4 stocks
Merck & Company Inc
MRK
▲ PositiveTechnologyrelevance

Merck's Keytruda combined with Moderna's intismeran autogene met primary and key secondary endpoints in the Phase III INTerpath-001 melanoma study.

Moderna Inc
MRNA
▲ PositiveTechnologyrelevance

Moderna's mRNA cancer therapy intismeran autogene achieved the first positive Phase III readout for an individualized neoantigen therapy.

Critical Materials & Supply Chain▲ · 1 stocks

Theme Impact 4

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