Shanghai Model Organisms Center, Inc. is engaged in the research, development, production, sale, and related technical services of genetically modified animal models. The company uses model organisms such as mice, rats, zebrafish, and nematodes as carriers, applying gene editing technology to introduce or delete target DNA fragments. It offers a toolbox of mice, including disease models for rare, infectious, and nervous system diseases, cardio-metabolic, autoimmune, and spontaneous tumor models, as well as target humanized knock-ins covering tumor targets, immune checkpoints, complements, cytokines, and metabolic and other targets, along with cytokine reporters, inducible cell ablation, and cell-specific reporters. The company also provides other models including rats (humanized drug targets, immunodeficient, disease, reporter, and cre-driver models), standard strains (inbred and outbred), cell models (reporter-labeled, primary, wild-type, and others), and supporting solutions such as colony management (cryopreservation and cryorecovery, housing and management, genotyping analysis, and breeding services) and auxiliary apparatuses like the e-BLOT WB imaging system. Additionally, it offers preclinical services including non-GLP toxicology, pharmacokinetics, phenotype analysis, and pharmacology and pharmacodynamics, and treatments for therapeutic areas such as oncology, nervous system, autoimmune, and digestive system diseases. The company was founded in 2000 and is headquartered in Shanghai, China.