BioXcel Therapeutics, Inc., with its subsidiary OnkosXcel Therapeutics LLC, is a biopharmaceutical company that uses artificial intelligence approaches to develop medicines in neuroscience and immuno-oncology in the United States. The company has IGALMI, a sublingual film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder in adults. It also develops BXCL501, an investigational proprietary orally dissolving sublingual film formulation of dexmedetomidine in Phase 3 trials for agitation associated with bipolar disorders, schizophrenia, and Alzheimer's disease, as well as opioid use disorder, alcohol use disorder with comorbid post-traumatic stress disorder, and acute stress disorder; and BXCL701, an investigational oral innate immune activator that has completed Phase 1b/2a trials for aggressive forms of prostate cancer, pancreatic cancer, and other solid and liquid tumors. In addition, the company is developing BXCL502 for stress-related neuropsychiatric symptoms in dementia and other stress-related disorders; BXCL503, a drug candidate targeting apathy in dementia; and BXCL504, which has the potential to address apathy and aggression in dementia. The company has collaborations with Columbia University, Yale University Medical School, and University of North Carolina for the development of BXCL501. BioXcel Therapeutics, Inc. was incorporated in 2017 and is headquartered in New Haven, Connecticut. On August 27, 2026, BioXcel Therapeutics, Inc., along with its affiliates, filed a voluntary petition for reorganization under Chapter 11 in the U.S. Bankruptcy Court for the District of Delaware.