Jaguar Health, Inc. is a commercial-stage pharmaceuticals company focused on developing plant-based prescription medicines for people and animals with gastrointestinal distress. It operates through two segments: Animal Health and Human Health. Its lead prescription drug is Mytesi, an anti-secretory antidiarrheal drug for symptomatic relief of non-infectious diarrhea in adults with HIV/AIDS on antiretroviral therapy, and Canalevia-CA1, a prescription drug for chemotherapy-induced diarrhea in dogs. The company is also developing Crofelemer in Phase III trials for prophylaxis of diarrhea in adult cancer patients and in Phase II trials for rare/orphan disease indications, diarrhea-predominant irritable bowel syndrome, and idiopathic/functional diarrhea. Additionally, it is developing Mytesi in Phase III trials for cancer therapy-related diarrhea and Phase II trials for irritable bowel syndrome, as well as NP-300, a second-generation antidiarrheal drug in Phase I trials for moderate-to-severe diarrhea. The company is headquartered in San Francisco, California.