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Nexentis Technologies Inc.

Nexentis Technologies Inc., through its subsidiary, develops therapeutics for cancer and inflammatory metabolic diseases. It operates in two segments: Biotechnology Activity and Renewable Energy Projects. Its pipeline includes MITOLINE, an algorithm for multiple sequence and structure pairwise alignments that can be used to generate 3D comparative models of mitochondrial carrier proteins, as well as a cloud-based computational chemistry platform, novel in-vitro screening platforms, and advanced 3D NSCLC tumor spheroid systems. The company was formerly known as N2OFF, Inc. and changed its name to Nexentis Technologies Inc. in February 2026. It was incorporated in 2009 and is headquartered in Ness Ziona, Israel.

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Biotech & Genomic Medicine

Nexentis Shares Swing After Subsidiary Reaches Drug Discovery Research Milestone

Nexentis Technologies experienced sharp trading volatility after its biotechnology subsidiary MitoCareX Bio completed a broad structural assessment of human Solute Carrier transport proteins, a milestone that could broaden its small-molecule drug discovery platform. The stock initially surged as much as 30% before reversing course and trading about 2% lower later in the session. The analysis identified additional SLC proteins outside the SLC25 family whose amino acid structures appear compatible with MitoCareX's proprietary MITOLINE technology, prompting plans to investigate whether MITOLINE-generated 3D models can be used in virtual screening for non-mitochondrial SLC targets. Chief Executive Officer David Palach said the findings demonstrate the flexibility and potential of the MITOLINE platform and the company's ability to identify additional transporter targets. Nexentis also invests in solar energy projects through a Ready-to-Build development model, providing exposure to both healthcare innovation and renewable energy infrastructure.
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Biotech & Genomic Medicine

MitoCareX Bio Completes Broad Structural Analysis of SLC Transport Proteins

Nexentis Technologies announced that its subsidiary MitoCareX Bio has completed a broad structural analysis of human SLC transport proteins. The analysis builds on MitoCareX’s proprietary MITOLINE algorithm and has identified additional SLC proteins outside the SLC25 family that may be compatible with MITOLINE-enabled 3D modeling. MitoCareX intends to explore using these models in virtual screening workflows to potentially expand its small-molecule discovery efforts into new disease-relevant transporters. CEO David Palach said the achievement highlights the strength and versatility of the MITOLINE platform and supports the company’s goal of delivering breakthroughs in hard-to-treat cancers and inflammatory metabolic diseases.
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