Rapport Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing small molecule medicines for central nervous system (CNS) disorders. Its lead candidate, RAP-219, is an investigational small molecule designed to inhibit TARPy8-containing AMPARs with picomolar affinity for focal epilepsy and other CNS disorders, including peripheral neuropathic pain and bipolar disorder. The company also develops nicotinic acetylcholine receptor (nAChR) programs, such as a6 nAChR for chronic pain and migraine, and a9a10 nAChR for hearing and vestibular disorders. Formerly Precision Neuroscience NewCo, Inc., it changed its name to Rapport Therapeutics, Inc. in October 2022, was incorporated in 2022, and is headquartered in Boston, Massachusetts.