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Relay Therapeutics Inc

Relay Therapeutics, Inc. is a clinical-stage precision medicines company focused on enhancing small molecule therapeutic discovery in targeted oncology and genetic disease indications. Its lead product candidates include RLY-2608, a pan-mutant and isoform-selective PI3Kα inhibitor in clinical development for breast cancer, solid tumors, and vascular malformations, and aGal chaperone for Fabry disease. It also develops RLY-8161, an oncogene driver in the RAS family, and lirafugratinib (RLY-4008), a receptor tyrosine kinase for cancer treatment. The company has collaboration and license agreements with D. E. Shaw Research, Elevar Therapeutics, and Pfizer Inc. Formerly known as Allostery, Inc., it changed its name to Relay Therapeutics, Inc. in December 2015, was incorporated in 2015, and is headquartered in Cambridge, Massachusetts.

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Biotech & Genomic Medicine

Relay Therapeutics selects zovegalisib plus atirmociclib triplet for Phase 3 frontline breast cancer trial

Relay Therapeutics has selected the combination of zovegalisib plus atirmociclib as its go-forward triplet regimen for first-line breast cancer, with a Phase 3 trial in endocrine-sensitive patients expected to begin in early 2027 pending regulatory feedback. The company also presented initial positive clinical data from the Phase 1/2 ReInspire trial of zovegalisib in vascular anomalies at the ISSVA World Congress 2026, where 60% of patients achieved a volumetric response at 12 weeks, and opened expansion cohorts. Relay continues to execute the ongoing Phase 3 ReDiscover-2 trial of zovegalisib plus fulvestrant in second-line breast cancer. As of June 30, 2026, the company held approximately $911 million in cash, cash equivalents and investments, which it expects will fund operations into 2029. Net loss for the second quarter was $83.7 million, or $0.41 per share, compared to a net loss of $70.4 million, or $0.41 per share, in the same period last year.
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