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Surrozen Inc

Surrozen, Inc. is a biotechnology company that discovers and develops product candidates to selectively modulate the Wnt pathway for tissue repair. Its lead candidates are antibody-based therapeutics targeting diseases of the eye, intestine, liver, lung, retina, kidney, cochlea, cornea, skin, pancreas, and central nervous system. The company is developing SZN-814, which combines Frizzled 4 (Fzd4) agonism and vascular endothelial growth factor (VEGF) antagonism for diabetic macular edema (DME), neovascular age-related macular degeneration (wet AMD), and retinopathy; SZN-8143, which combines Fzd4 agonism, VEGF antagonism, and interleukin-6 (IL-6) for DME, wet AMD, and uveitic macular edema; and SZN-413, a Fzd4-targeted bi-specific antibody for retinal vascular associated diseases. Surrozen has a collaboration and license agreement with Boehringer Ingelheim International GmbH to research, develop, and commercialize Fzd4 bi-specific antibodies, and a research collaboration agreement with TCGFB, Inc. to discover antibody therapeutics targeting transforming growth factor beta (TGF-ß) for idiopathic pulmonary fibrosis. Founded in 2015, Surrozen is headquartered in South San Francisco, California.

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Surrozen Plans IND for SZN-8141 by Q3 2026, Phase 1b/2a Trial by Year-End

Surrozen announced plans to submit an Investigational New Drug application for its lead ophthalmology candidate SZN-8141 by the end of the third quarter of 2026 and to initiate the DUET Phase 1b/2a study in diabetic macular edema patients by year-end 2026, with initial data expected in the second half of 2027. The U.S. Patent Trial and Appeal Board denied institution of a post-grant review petition challenging Surrozen’s patent, reinforcing its intellectual property position. The company reported second-quarter 2026 net income of $50.2 million, including non-cash gains of $59.6 million from changes in fair value of tranche and warrant liabilities, compared to net income of $39.7 million in the same period of 2025. Collaboration and license revenue was $5.0 million, attributable to a milestone achieved under a collaboration agreement with Boehringer Ingelheim, while research and development expenses rose to $8.5 million from $6.0 million a year earlier. Cash and cash equivalents stood at $102.0 million as of June 30, 2026.
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