AbbVie Immunology Sales Hit $16.1 Billion as Skyrizi and Rinvoq Offset Humira Erosion

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AbbVie's immunology franchise generated $16.1 billion in first-half 2026 sales, more than half of the company's total sales, as Skyrizi and Rinvoq continued to offset the biosimilar erosion of Humira that began in the United States in 2023. The segment's sales rose nearly 16% year over year on a reported basis, outpacing AbbVie's overall revenue growth, and the company expects combined Skyrizi and Rinvoq sales to exceed $31 billion in 2026. Rinvoq was approved in the EU in July for vitiligo and alopecia areata, and AbbVie believes those two indications alone can add up to $2 billion in combined peak sales, while phase III data for Rinvoq in hidradenitis suppurativa and systemic lupus erythematosus are expected later this year. Supported by those two drugs, AbbVie expects high-single-digit compound annual revenue growth through 2029, with no major loss-of-exclusivity events expected to materially disrupt the business through the rest of the decade. Beyond its current leaders, AbbVie is evaluating Skyrizi-based combination regimens with ABBV-382 and ABBV-701 in inflammatory bowel disease, seeking approval for a subcutaneous induction regimen of Skyrizi in Crohn's disease, and has added pipeline assets through acquisitions including Nimble Therapeutics, Capstan Therapeutics and Apogee Therapeutics, whose zumilokibart is a phase III-ready long-acting anti-IL-13 antibody for atopic dermatitis that AbbVie believes can compete with Dupixent.

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Immunology franchise sales hit $16.1B in H1 2026, up ~16% YoY, with Skyrizi and Rinvoq offsetting Humira biosimilar erosion.

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