Kymera Therapeutics IncCompleted enrollment in Phase 2b trial of KT-621 ahead of schedule, accelerating data readout and Phase 3 plans.

Kymera Therapeutics has completed enrollment in the global Phase 2b BROADEN2 trial of its oral STAT6 degrader KT-621 for moderate to severe atopic dermatitis nearly six months ahead of anticipated timelines. The earlier-than-expected completion allows the company to accelerate its expected topline data readout to year-end 2026, six months earlier than prior guidance of mid-2027. Subject to regulatory discussions, Kymera plans to initiate Phase 3 trials in atopic dermatitis by mid-2027. The BROADEN2 study is evaluating three doses of KT-621 in approximately 200 patients aged 12 to 75 over 16 weeks, with the primary endpoint being percent change from baseline in Eczema Area and Severity Index score at Week 16. KT-621 is also being evaluated in the ongoing BREADTH Phase 2b trial in moderate to severe eosinophilic asthma, with data expected in late 2027.
Kymera Therapeutics IncCompleted enrollment in Phase 2b trial of KT-621 ahead of schedule, accelerating data readout and Phase 3 plans.