Spyre Therapeutics Inc.Phase II SKYLIGHT study of SPY772 in HS expands pipeline beyond IBD, with topline data expected by 2028.
Spyre Therapeutics expanded its inflammatory-disease strategy in August with SPY772 and the phase II SKYLIGHT study in hidradenitis suppurativa, or HS, moving its combination approach into a new disease area beyond inflammatory bowel disease and rheumatology. SKYLIGHT is evaluating SPY072 plus bimekizumab against bimekizumab alone in approximately 150 adults with moderate-to-severe HS, with the primary endpoint of HiSCR75 response rate at week 16 and topline data expected in late 2027 or early 2028. The study tests whether adding SPY072 to bimekizumab can improve the week-16 response rate relative to bimekizumab alone, and positive results could support further SPY772 development in HS and other indications. Spyre's pipeline already spans ulcerative colitis, rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis, and the company is advancing multiple IBD monotherapies and dual-antibody combinations. Competition in HS includes AbbVie's established Humira and its developing ABBV-1451, as well as Incyte's FDA-accepted New Drug Application for povorcitinib with a U.S. launch targeted for the first quarter of 2027 if approved. Research and development expenses rose 63.2% year over year to $65.5 million in the second quarter of 2026, and Spyre ended the quarter with $1.15 billion in cash, cash equivalents and marketable securities, which management expects to fund operations into the second half of 2029.
Spyre Therapeutics Inc.Phase II SKYLIGHT study of SPY772 in HS expands pipeline beyond IBD, with topline data expected by 2028.
AbbVie IncSpyre's SPY772 study in HS could compete with AbbVie's Humira and ABBV-1451.
Incyte CorporationSpyre's HS study adds competition to Incyte's povorcitinib, which is awaiting FDA approval.