Amgen IncTEZSPIRE met all endpoints in Phase III EoE trial, expanding its potential indications.
AstraZeneca and Amgen announced positive high-level results from the Phase III CROSSING trial, showing that TEZSPIRE (tezepelumab-ekko) achieved statistically significant and clinically meaningful improvements across both co-primary and all key secondary endpoints in patients with eosinophilic esophagitis (EoE) at week 24, with effects sustained through week 52 in both doses tested. The co-primary endpoints were histologic remission and the frequency and severity of dysphagia compared to placebo, and the safety profile was consistent with approved indications. EoE is a chronic inflammatory disorder affecting over 470,000 people in the US, and nearly half of patients do not achieve adequate control with current first-line treatments. The results mark the third epithelial-driven inflammatory disease where TEZSPIRE has shown efficacy, and full results will be shared with regulatory authorities and at an upcoming medical meeting.
Amgen IncTEZSPIRE met all endpoints in Phase III EoE trial, expanding its potential indications.
AstraZeneca PLCTEZSPIRE met all endpoints in Phase III EoE trial, expanding its potential indications.